Vision & Intellectual Property

Valtari Bio focuses on biomarker-based tools for use across the continuum of stroke care with an emphasis on improving patient outcomes and the highest level of clinical utility. Our intellectual property portfolio includes innovative biomarker approaches in stroke diagnosis, treatment, and recovery.

Relevant Publications

O’Connell G, Stafford P, Walsh K, Adeoye O, Barr T. High-throughput profiling of circulating antibody signatures for stroke diagnosis using small volumes of whole blood.  Neurotherapeutics. July 2019, Volume 16, Issue 3, pp 868–877

Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood-brain barrier disruption. Grant C. O’Connell, Madison B. Treadway, Ashley B. Petrone, Connie S. Tennant, Noelle Lucke-Wold, Paul D. Chantler & Taura L. Barr. Scientific Reports 7, Article number: 1172 (2017).

Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population. O’Connell GC, Chantler PD, Barr TL. Genomics Data. Volume 14, December 2017, Pages 47–52.

Circulating extracellular DNA levels are acutely elevated in ischemic stroke and associated with innate immune system activation. Grant C. O’Connell, Ashley B. Petrone, Connie S. Tennant, Noelle Lucke-Wold, Yasser Kabbani, Abdul R. Tarabishy, Paul D. Chantler & Taura L. Barr. Brain Injury. June 2017.

Machine-learning approach identifies a pattern of gene expression in peripheral blood that can accurately detect ischemic stroke. O’Connell GC, Petrone AB, Treadway MB, Tennent CS, Lucke-Wold N, Chantler, PD, Barr TL. npj Genomic Medicine. November 2016.

The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Ashley B. Petrone, BS; Grant C. O’Connell, MS; Michael D. Regier, PhD; Paul D. Chantler PhD; James W. Simpkins, PhD; and Taura L. Barr, PhD RN. Translational Stroke Research. April 2016, Volume 7, Issue 2, pp 103-110.

A genomic profile of the immune response to stroke with implications for stroke recovery. Barr TL, VanGilder R, Rellick S, Brooks SD, Doll DN, Lucke-Wold AN, Chen D, Denvir J, Warach S, Singleton A, Matarin M, Biol Res Nurs. 2015 May;17(3):248-56. doi: 10.1177/1099800414546492. Epub 2014 Aug 14.

Admission neutrophil-lymphocyte ratio predicts 90-day outcome after endovascular stroke therapy. Brooks SD, Spears C, Cummings C, VanGilder RL, Stinehart KR, Gutmann L, Domico J, Culp S, Carpenter J, Rai A, Barr TL. J Neurointerv Surg. 2014 Oct;6(8):578-83. doi: 10.1136/ neurintsurg-2013-010780. Epub 2013 Oct 11.

Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling. Barr TL, Conley Y, Ding J, Dillman A, Warach S, Singleton A, Matarin M. Neurology. 2010 Sep 14;75(11):1009-14. doi: 10.1212/WNL.0b013e3181f2b37f.